Buy Thyroxine

The thyroid gland secretes mainly T4 (thyroxine), in itself this hormone has a weak biological activity, but in tissues it is converted into a more active form of T3 (triiodothyronine or cytomel) by the enzyme of selenium-dependent monodeiodinase. T3, in turn, has a major biological effect. Thus, we can consider T4 as a prohormone, which in tissues turns into the main hormone T3.

 

On many resources, triiodothyronine is considered the best choice, but scientific evidence suggests otherwise.

A quote from Goodman's Clinical Pharmacology, the latest 12th edition from 2010 is the most authoritative book on pharmacology in the world:

 

Liothyronine is less desirable for chronic replacement therapy due to the requirement for more frequent dosing (plasma t1/2 = 0.75 days), higher cost, and transient elevations of serum T3 concentrations above the normal range. In addition, organs that express the type 2 deiodinase use the locally generated T3 in addition to plasma T3, and hence there is theoretical concern that these organs will not maintain physiological intracellular T3 levels in the absence of plasma T4.

 

Total we get:

 

• T3 creates undesirable fluctuations in concentration
• Tissues with type 2 deiodinase use additionally triiodothyronine, which is formed from T4 within the cell. This means that the intracellular level of T3 in these tissues will be lower, even if the concentration of thyroxine remains unchanged (and when taking the drug for burning fat it will become below the norm). From any source, you can find out that type 2 deiodinase is synthesized in adipose tissue.
• According to athletes, T4 has less destructive effect on the muscles.
• 25-100 μg / day T3 is equivalent to ≈300 μg / day T4
• T3 is significantly more expensive

 

From the above arguments it follows that thyroxine is preferable to fat burning, at least by three criteria. In rare cases, T4 is not very effective because the low-carbohydrate diet reduces the level of its conversion to T3.

• Tachycardia (palpitation), increased blood pressure - is eliminated by beta-blockers (metoprolol, bisoprolol);
• Osteoporosis;
• Diarrhea - eliminated by loperamide;
• Excitement;
• Insomnia;
• Muscle trembling;
• Dry mouth;
• Sweating;
• Feeling of heat;
• Decreased thyroid function (occurs with long courses and very high doses of thyroxin, with the use of recommended doses, the function is restored after 3-4 weeks);
• Allergic rash.

Many women and bodybuilders resort to using thyroxine as a means of losing weight. Thyroxin has a powerful fat-burning effect, increases caloric intake and accelerates metabolism.
Its popularity has decreased recently due to the negative impact on the heart, thyroxine has an adrenaline-like effect, causing the heart to beat more often, and with it causes a feeling of excitement and anxiety that is not well tolerated.

However, many side effects can be eliminated if you combine thyroxine and beta-blockers(metoprolol, bisoprolol). Beta-blockers inhibit the receptors through which thyroxine affects the heart, so they prevent the negative effect of thyroxine on the heart, normalize the rhythm and reduce the manifestation of some other side effects of thyroxin.

 

Many people believe that thyroxine can irreversibly suppress the function of its own thyroid gland, but studies have shown that even large doses of the drug in 3 weeks of intake reduce the secretion of their own hormones by only 20%, and after 4 weeks, the secretion returned to normal.

Advantages of thyroxine: high availability and effectiveness. Disadvantages of thyroxine: a rather large number of side effects, but many of them can be prevented.

• Start thyroxine intake from 50 μg per day, 2 times a day (25 μg each) in the first half of the day. In the morning, take 25 mg metoprolol (beta-blocker, which eliminates heart overload and heartbeat) if the pulse rate after lunch is above 70 beats. per minute at rest, then take another 25 mg of metoprolol.
• Gradually increase the dose to 150-300 mcg per day, 3 times a day until 18:00. Increase the daily dose of metoprolol to 100 mg (twice a day for 50 mg). Metoprolol dosage is selected individually, so that the heart rate at rest is 60-70 beats. in a minute.
• Reduce the dose of thyroxine if there are significant side effects.
• Monitor the heart rate, if at rest the heart rate is higher than 80 - increase the dose of metoprolol by 25 mg, if the pulse at rest is below 60 beats per minute, reduce the dose of metoprolol by 25 mg.
• Watch your blood pressure, it should not be above 140/90 mm Hg. Art. Metoprolol helps to lower blood pressure.
• Duration 4-7 weeks.
• Do not stop taking thyroxine abruptly: start lowering the dose 2 weeks before the end of the cycle, continue the gradual decrease until complete withdrawal.
• If you have diarrhea - include loperamide in the course of 1-2 capsules per day.
• The minimum break after the completion of the course is 3-4 weeks.
• If there is heaviness in the heart, it is better to add Asparkam in addition to Metoprolol. 4-6 tablets per day, divided into 2-3 meals, after meals. Also, it will not be superfluous to improve the heart function with Riboxin. 2-4 tablets at a time, 2-3 times a day. Riboxin will improve the energy balance of the myocardium, and Asparkum will become a source of potassium and magnesium, necessary to maintain a normal heart rate.

More effective and safe course of thyroxin you can buy from us:

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