Buy Higenamine (Norcoclaurine)

In animal models, higenamine has been shown to be an agonist of β 2 -adrenergic receptors. Adrenergic receptors or adrenergic receptors belong to the class of G-protein coupled receptors and are the most prominent receptors in the adipose membrane, in addition to expression in skeletal muscle tissue. These fat membrane receptors are classified as α- or β-adrenergic receptors. Although these adrenergic receptors share the same messenger, cyclic adenosine monophosphate (cAMP), the specific transduction pathway depends on the type of receptor (α or β). Higenamine exerts its action in part by activating the enzyme adenylate cyclase, which is responsible for increasing the cellular concentration of the adrenergic secondary messenger cAMP. In a rodent model, higenamine was found to have cardiotonic, vascular relaxation and bronchodilator effects. In particular, higenamine, through the mechanism of beta-adrenergic receptors, induced relaxation of the rat cavernous body, which led to an improvement in vasodilation and erectile function. In connection with improved vasodilator signals in animal models, higenamine has been shown to have antiplatelet and antithrombotic activity via the cAMP-dependent pathway, suggesting that higenamine may enhance vasodilation and arterial integrity.

In humans, higenamine is being studied as an investigational drug in China for use as a pharmacological agent in cardiac stress tests and for the treatment of a number of heart conditions, including bradyarrhythmia. Human trials were relatively small (10 to 120 subjects), and higenamine was administered intravenously, most often using gradual infusions of 2.5 or 5 mg. Higenamine continually increased the heart rate, but had different effects on blood pressure. One small study described the effect of higenamine on cardiac output: higenamine increased the ejection fraction in 15 patients with heart disease.

The safety of oral higenamine in humans is unknown. During the acute toxicity study, mice were orally administered the compound at a dose of 2 g per kg of body weight. During the study, not a single mouse died. In human trials of intravenous higenamine, subjects receiving higenamine reported shortness of breath, palpitations, dizziness, headaches, and chest tightness.

Higenamine, also known as norkoclaurine HCl, is approved for use in dietary supplements in the UK, EU, US and Canada. Its main uses are nutritional supplements designed for weight management and sports supplements. Traditional higenamine preparations have been used in Chinese medicine for thousands of years and come from a variety of sources, including fruits and orchids. There are no studies comparing the safety of modern formulations (based on synthetic higenamine) with traditional formulations. However, it will not be added to the EU “new food” catalog, which details all food additives that require a safety assessment certificate before use.

Like many other β 2 agonists, higenamine is banned by the World Anti-Doping Agency for use in sports. In 2016, French footballer Mamadou Saho was temporarily blocked by UEFA after testing positive for higenamine, which caused the player to miss the 2016 Europa League final. The ban was lifted after the player successfully proved that there was no gross negligence, as the substance was not on the list of prohibited substances, despite the fact that drugs in the same category - β 2 agonists - were banned.

Use 1-2 capsules 30 minutes before physical activity.

Higenamine (100 mg × 30 caps) may have a temporary effect and should not be taken with or after using pre-workouts (especially with mind / mood stimulants) - you can become overly aggressive and lose control of your weight and exercise intensity.

Not for persons under the age of 18. Do not use if pregnant or breastfeeding. This product is not intended as a substitute for a sleep stimulant.

KEEP OUT OF THE REACH OF CHILDREN AND PETS. STORE IN A COOL, DRY PLACE.

You can buy Higenamine from our website absolutely legally.

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We guarantee that you will receive your parcel with Higenamine without any problems at customs (we have our own delivery channels to countries with strict customs).

We guarantee a refund if your package has not been delivered to you for any reason, according to PayPal protection policy.

Due to Quarantine, delivery time may increase slightly, but still delivery remains within reasonable limits and does not exceed the delivery time during Christmas sales.

There is no prescription required!

You can legally buy Higenamine on our website without prescription!