Buy Naloxone

The drug dose and administration route depend on the patient's condition and the amount of opioid agonist presented in the body.

 

For opioid analgesic intoxication, the initial dose of Naloxone is 0.4-2 mg intravenously slowly (for 2-3 min), intramuscularly or subcutaneously.

In life-threatening conditions, the intravenous route of administration is preferred.

Repeated doses may be administered after 2-5 min until consciousness is restored and spontaneous breathing is restored.

If recovery of consciousness and respiration does not occur after administration of a total dose of Naloxone 10 mg, the other (neopioid) cause of poisoning should be considered.

 

The initial dose for children is 5-10 µg/kg body weight. Repeated administration of the drug is possible if necessary.

 

 

To speed up the exit from surgical anesthesia, Naloxone is prescribed in lower doses - from 100 to 200 µg (1.5-3 µg/kg) every 2-3 minutes until adequate pulmonary ventilation appears and the patient wakes up, but without any distinct pain and discomfort.

A dose more than the minimum required may cause analgesia to stop and increase BP, as well as other symptoms such as nausea, vomiting, increased sweating, and discirculatory crisis.

 

The initial dose of Naloxone for children is 1-2 µg/kg of body weight intravenously.

If the desired effect is not achieved, the drug is reintroduced in doses of up to 100 µg/kg of body weight every 2 minutes, until spontaneous breathing and consciousness recovery.

If intravenous injection is not possible, the drug should be injected intramuscularly or subcutaneously in fractional doses.

 

For newborns, the initial dose is 10 µg/kg body weight.

 

Administration may be repeated in adults with postoperative respiratory depression in the presence of opioid analgesics.

 

 

In respiratory depression caused by opioid analgesics injected into the mother during perinatal anesthesia, newborns are given an initial dose of 1-2 µg/kg Naloxone intramuscular, subcutaneous or intravenous.

If there is no effect, the drug is injected again in a dose of up to 100 µg/kg of body weight every 2 minutes until spontaneous respiration and recovery.

Before administering the drug it is necessary to check the airway passability of the newborn child.

Prophylactic intramuscular administration of 200 µg (60 µg/kg body weight) of Naloxone is possible.

 

 

To diagnose opioid dependence, 800 µg Naloxone is administered intravenously and the patient is monitored for signs of withdrawal.

 

You can inject the drug:

 

• Intramuscular;

 

• Intravenously;

 

• Subcutaneously.

 

According to research data, regardless of the way naloxone enters the body, it has the necessary action. However, the fastest result is achieved when the substance enters the bloodstream directly.

 

Naloxone's action lasts about 30 minutes on average. If the condition becomes worse at the end of this time, a second injection is necessary.

 

 

Symptoms: nausea, vomiting, AH (arterial hypertension), ventricular tachycardia, ventricular fibrillation, cardiac arrest, pulmonary edema.

 

Treatment: symptomatic. To prevent overdose, strictly follow the recommended doses of the drug.

Hypersensitivity.

Digestive system: nausea, vomiting.

 

Cardiovascular system: tachycardia, arterial hypertension, cardiac arrest.

 

CNS: tremors, seizures.

 

Others: increased sweating.

 

In case of use in therapeutic doses for patients who do not contain opioids, Naloxone usually causes no side effects.

 

If Naloxon is used in the postoperative period in doses exceeding the minimum required, the disappearance of analgesia and excitation, arterial hypotension, ventricular tachycardia, fibrillation, pulmonary oedema is possible.

 

Withdrawal syndrome in opioid-dependent patients: pain of unspecified localization, diarrhea, hyperthermia, rhinorrhea, sneezing, "goose skin", sweating, nausea, vomiting, fatigue, tremor, spasms in the epigastric region;

 

Newborns - seizures, diarrhea, hyperthermia, unrestrained crying, hyperreflexia, sneezing, tremor, marked irritability, vomiting.

• small amount of side effects;

 

• reasonable price;

 

• no development of addiction and the formation of drug dependence;

 

• lack of contraindications.

Naloxone and naltrexone are pure blockers of opiate receptors. 

 

Naloxone is used to restore independent breathing in case of opioid overdose. 

It is administered parenterally, selecting the dose in such a way that it ensures the safety of breathing reflexes and normal ventilation.

 

Naltrexone is taken orally.

It is prescribed for opioid withdrawal during detoxification and abstinence and as an adjunctive agent for alcohol withdrawal.

 

Naloxone has low bioavailability when taken orally because of its destruction during first passage through the liver, but it absorbs well with any other route of administration.

The duration of Naloxone action is 20-90 min depending on the dose and route of administration, the dose that caused opioid poisoning and the rate of elimination of both drugs. 

The onset of naloxone action depends on the type of administration: with intravenous administration - 1-2 min, subcutaneous - an average of 5.5 min. There is no accurate data on intramuscular administration.

 

Naltrexone is rapidly absorbed during oral administration (bioavailability 5-60%), maximum serum concentration is reached after 1 hour. 

Duration of action - 8-24 hours.

 

Naloxone has lower amount of side effects in comparison to Naltrexone.

 

Naloxone is cheaper than Naltrexone.

Active ingredient:400 mcg hydrochloride naloxone.

Auxiliary substances: sodium chloride, hydrochloric acid, water for injection.

You can buy Naloxone from our website absolutely legally.

Delivery is carried out to all countries in the world, which do not have an official ban on receiving and sending mail (mainly island countries).

We guarantee that you will receive your parcel with Naloxone without any problems at customs (we have our own delivery channels to countries with strict customs).

We guarantee a refund if your package has not been delivered to you for any reason, according to PayPal protection policy.

Due to Quarantine, delivery time may increase slightly, but still delivery remains within reasonable limits and does not exceed the delivery time during Christmas sales.

There is no prescription required!

You can legally buy Naloxone on our website without prescription!