Buy Naltrexone

After ingestion, naltrexone is almost completely absorbed from the digestive tract. Naltrexone and its active metabolite 6 - naltrexol in blood plasma is achieved after 1 hour.

With prolonged use, naltrexone does not accumulate in the body, while the concentration of 6 - naltrexol in plasma reaches 40%. This is because the T1 / 2 metabolite is greater than that of naltrexone.

95% of the dose of naltrexone is biotransformed in the liver into pharmacologically active metabolites, the main of which is 6 - naltrexol is also an antagonist of opioids. The second metabolite is 2-hydroxy-3-methoxy-6 - naltrexol. Naltrexone and its metabolites undergo intrahepatic recirculation.

Naltrexone and its metabolites are excreted mainly by the kidneys. The amount of free naltrexone that is excreted in the urine is less than 1%, and the amount of free and bound 6 - naltrexol is approximately 38%. Average T1 / 2 naltrexone - 4 hours, 6 - naltrexol - 13 hours.

As an adjuvant for abstinence after the withdrawal of opioid analgesics.

Drug is taken internally. The drug is prescribed only after relief of the withdrawal syndrome and after a preliminary detoxification.The use of naltrexone is started in specialized drug treatment units 7-10 days after the last intake of the opioid drug. In the future, the patient must be under strict medical supervision, a positive attitude is necessary for the treatment of drug addiction in the patient.Treatment of alcoholism: Inside to 50 mg once a day, a 12-week course of treatment prevents relapse within 6 months (the success of treatment depends on the patient's consent).Treatment of drug dependence: They begin only after 7-10 days of abstinence from using opioids, confirmed by a provocative test and urine analysis for the content of opioids. The patient should have no "withdrawal" syndrome and signs of withdrawal. Treatment does not begin until a provocative trial with an intravenous injection of 0.5 mg of naloxone becomes negative. The initial dose of 25 mg, for 1 hour should monitor the patient's condition, in the absence of withdrawal syndrome - appoint 50 mg once a day, this dose blocks 25 mg of heroin administered intravenously. Alternative treatment regimens:1. 50 mg every weekday and 100 mg on a Saturday.2. 100 mg every other day.3. 150 mg in 2 days.4. 100 mg (on Monday), 100 mg (on Wednesday) and 150 mg (on Friday). It should be borne in mind that the use of these regimens increases the risk of hepatotoxicity. The course of treatment is determined individually.