Buy Mirtazapine

The drug is taken orally, preferably 1 time / day in the evening before bedtime. Possible application 2 times / day - in the morning and evening before bedtime.

Adults: The effective daily dose is usually from 15 mg to 45 mg; the initial dose is 15 mg or 30 mg. A higher dose should be taken at night.

Treatment should be continued as far as possible until complete absence of symptoms within 4-6 months. After this, the drug can be gradually canceled.

Therapeutic effect is usually manifested after 1-2 weeks of treatment. Treatment with an adequate dose should result in a positive response in 2-4 weeks. If the response to treatment is insufficient, the dose can be increased to the maximum. In the absence of a therapeutic response, after 2-4 weeks treatment should be discontinued.

For elderly patients, the recommended dose is the same as for adults. In this category of patients, in order to achieve a satisfactory and safe response to treatment, an increase in the dose should be carried out under the direct supervision of a physician.

In patients with renal or hepatic insufficiency, it is possible to slow the excretion of mirtazapine from the body. This should be taken into account when prescribing a drug in this category of patients.

The tablets covered with a film cover, it is necessary to wash down with a liquid and to swallow without chewing.

The tablet for resorption should be put on the tongue and dissolve until it completely disintegrates. Tablets for resorption quickly destroyed in the language, for their intake does not require fluid. Before taking the drug and during its resorption, do not try to destroy the tablet (chew, break, etc.).

Mirtazapine should not be used in combination with MAO inhibitors or within 2 weeks after discontinuation of treatment with an MAO inhibitor.

Mirtazapine can enhance the sedative properties of benzodiazepines and other sedatives. Caution should be exercised when prescribing these medicines together with mirtazapine.

Mirtazapine can enhance the inhibitory effect of ethanol on the central nervous system. Therefore, patients should be warned about the need to avoid drinking alcohol.

If other serotonergic drugs are used (for example, selective serotonin reuptake inhibitors, venlafaxine) in combination with mirtazapine, there is a risk of interaction that may lead to the development of serotonin syndrome. Based on the post-registration experience of using the drug, it turned out that serotonin cider appears very rarely in patients receiving treatment with mirtazapine in combination with selective serotonin reuptake inhibitors or venlafaxine. If it is considered that such a combination is necessary, then carefully adjust the dose and directly monitor the signs of the onset of increased serotonergic action.

Mirtazapine at a dose of 30 mg 1 time / day caused a small but statistically significant increase in MHO in patients treated with warfarin. You can not exclude a more pronounced effect with a higher dose of mirtazapine. It is recommended to monitor MHO in case of treatment with warfarin in combination with mirtazapine.