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Children: for the symptomatic treatment of itching. At the age of 12 months to 6 years - from 1 to 2.5 mg / kg / day in several doses, from 6 years and older - from 1 to 2 mg / kg / day in several doses.

For sedation - 1 mg / kg for 1 hour before surgery, as well as an additional night before anesthesia.

Adults: for the symptomatic treatment of anxiety - 25-100 mg per day in separate dosage during the day or at night. The standard dose is 50 mg per day (12.5 mg in the morning, 12.5 mg in the afternoon, and 25 mg at night).

In severe cases, the dose may be increased to 300 mg per day.

For sedation in surgical practice, 50–200 mg (1.5–2.5 mg / kg IM) is administered 1 hour before surgery.

For symptomatic treatment of itching - the initial dose of 25 mg, if necessary, the dose can be increased 4 times (25 mg 4 times a day).

In older patients, treatment begins with a half dose. In renal and / or hepatic insufficiency, doses should be reduced.

A single maximum dose should not exceed 200 mg, the maximum daily dose - not more than 300 mg.

It is necessary to take into account the potentiating effect of hydroxyzine when it was administered jointly with drugs that depress the central nervous system, such as narcotic analgesics, barbiturates, tranquilizers, hypnotics, alcohol.In this case, their dosage should be adjusted individually. Co-administration with MAO inhibitors and anticholinergics should be avoided. The drug inhibits the pressure action of adrenaline and the anticonvulsant activity of phenytoin, and also interferes with the action of betahistine and cholinesterase blockers. The effect of atropine, belladonna alkaloids, digitalis, antihypertensive drugs, H2-receptor antagonists does not change under the action of hydroxyzine. It is an inhibitor of P450 2D6 and in high doses may cause interaction with CYP2D6 substrates. Since hydroxyzine is metabolized in the liver, an increase in its concentration in the blood can be expected when it is co-administered with drugs that inhibit hepatic enzymes.