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Sibutramine is administered orally 1 time per day. The dose is set individually depending on the tolerability and clinical efficacy.

An initial dose of 10 mg per day is recommended.
The drug should be taken in the morning without chewing and drinking a sufficient amount of liquid (a glass of water). The drug can be taken on an empty stomach or combined with meals. If, within 4 weeks from the start of treatment, a decrease in body weight by 5% or more is not achieved, then the dose is increased to 15 mg per day.
Treatment with Sibutramine should not last more than 3 months in patients who do not respond well to therapy, i.e. who, within 3 months of treatment, do not manage to achieve a 5% level of weight loss from the initial level. Treatment should not be continued if, with further therapy, after the achieved weight loss, the patient again gains 3 kg or more in body weight.

The duration of treatment should not exceed 1 year, since there are no data on efficacy and safety for a longer period of taking sibutramine.
Treatment with Sibutramine should be carried out in combination with diet and exercise under the supervision of a physician with practical experience in the treatment of obesity.