Buy Heptral (Ademetionine) online. PayPal

Other brands: Heptor.

Pharmacological group: hepatoprotector.

Dosage form: tablets (400 mg, 500 mg), powder lyophilisate with solvent ampoule (400 mg)

Release form: One package of Heptral/Heptor (Ademetionine) consists of 20 tablets or 5 ampules.

Ademetionine is a hepatoprotective agent with antidepressant properties. The active substance of the drug is ademetionine - a biological substance that is part of all tissues and body fluids, but most of it is formed in the liver. Heptral is a source of an active amino acid important for liver function, it stimulates the natural * restoration of the structure of liver cells from the inside. Heptral® helps to eliminate toxins and improve vital liver functions after the 1st week of use.

Indication for use:

Alcohol related liver disease;
Intrahepatic cholestasis;
Fibromyalgia;
Depression;
Osteoarthritis.

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Buy Heptral (Ademetionine)

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Aantal

Ademetionine belongs to the group of hepatoprotectors, it also has antidepressant activity. It has choleretic and cholekinetic effects, has detoxifying, regenerating, antioxidant, anti-fibrosing and neuroprotective properties. Replenishes the deficiency of S-adenosyl-L-methionine (ademetionine) and stimulates its production in the body, is found in all environments of the body. The highest concentration of ademetionine was found in the liver and brain.

Plays a key role in the metabolic processes of the body.

Increases the content of glutamine in the liver, cysteine and taurine in plasma; reduces the content of methionine in serum, normalizing metabolic reactions in the liver. After decarboxylation, it participates in aminopropylation reactions as a precursor of polyamines - putrescine (stimulator of cell regeneration and proliferation of hepatocytes), spermidine and spermine, which are part of the ribosome structure, which reduces the risk of fibrosis. It has a choleretic effect.

Ademetionine normalizes the synthesis of endogenous phosphatidylcholine in hepatocytes, which increases the fluidity and polarization of membranes. This improves the function of the bile acid transport systems associated with the membranes of hepatocytes and promotes the passage of bile acids into the biliary tract. Effective for intralobular cholestasis (violation of the synthesis and flow of bile).

Ademetionine reduces the toxicity of bile acids in the hepatocyte, carrying out their conjugation and sulfation. Conjugation with taurine increases the solubility of bile acids and their excretion from the hepatocyte. The process of sulfation of bile acids contributes to the possibility of their elimination by the kidneys, facilitates the passage through the membrane of the hepatocyte and excretion with bile. In addition, the sulfated bile acids themselves additionally protect the membranes of liver cells from the toxic effect of non-sulfated bile acids (present in high concentrations in hepatocytes during intrahepatic cholestasis). In patients with diffuse liver diseases (cirrhosis, hepatitis) with intrahepatic cholestasis syndrome, ademetionine reduces the severity of itching and changes in biochemical parameters, incl. concentration of direct bilirubin, alkaline phosphatase activity, aminotransferases. The choleretic and hepatoprotective effect lasts up to 3 months after stopping treatment.

It has been shown to be effective in hepatopathies caused by various hepatotoxic drugs.

Antidepressant activity manifests itself gradually, starting from the end of the first week of treatment, and stabilizes within 2 weeks of treatment.

A number of studies have confirmed the effectiveness of ademetionine in the treatment of increased fatigue in patients with chronic liver disease. Treatment with ademetionine significantly improved mood in patients with alcoholic liver disease, who simultaneously achieved a positive response from symptoms of increased fatigue. In addition, in patients with alcoholic liver disease and non-alcoholic fatty liver disease with an achieved response to treatment with ademetionine in terms of symptoms of increased fatigue, a significant reduction in symptoms such as icterus of the skin and mucous membranes, malaise and itching was also observed.
The Ademetionine molecule has 3 active centers that provide general key reactions to restore the structure and function of liver cells:

1st ACTIVE CENTER participates in the synthesis of phospholipids of cell membranes, and restores cell structures. The structure of the liver cell is restored, the work of transport channels that ensure the excretion of bile is normalized.

2nd ACTIVE CENTER stimulates the division of healthy liver cells, providing regeneration processes and slowing the progression of liver diseases.

3rd ACTIVE CENTER participates in the synthesis of glutathione - a molecule that provides detoxification and protection from free radicals. Additionally, this active center is involved in the synthesis of ATP - energy molecules that replenish the energy potential of the cell. * methylation reactions (methyl group transfer)
Hypersensitivity,

genetic disorders affecting the methionine cycle and / or causing homocystinuria and / or hyperhomocysteinemia (cystathionine beta synthase deficiency, impaired vitamin B12 metabolism),

first six months of pregnancy,

childhood;

bipolar disorder.

Precautionary measures

Given the tonic effect of the drug, it is not recommended to take it before bedtime. With cirrhosis of the liver with concomitant azotemia, close medical supervision and a systematic study of the level of nitrogen in the blood should be carried out.
Heartburn,

pain or discomfort in the epigastric region,

mild dyspeptic symptoms,

sleep disturbances,

increased anxiety,

allergic reactions,

headache,

dizziness.

In bipolar depression Ademetionine can induce affect inversion (mania).
The tablets should be taken orally whole, without chewing, preferably in the morning between meals.

The recommended dose is 10-25 mg ademetionine per 1 kg of body weight per day. Usually, the daily dose is 1-2 tablets per day (from 400-800 mg ademetionine per day) and can be increased to 4 tablets per day (up to 1600 mg ademetionine per day).

The effect usually appears after 7-14 days of treatment and persists with further use of the drug. In the absence of a positive effect from the drug therapy carried out within 2 weeks or if the condition worsens, you should consult a doctor.

The tablets of the Heptral drug should be removed from the blister immediately before ingestion. If the tablets have a color different from white to white with a yellowish tinge (due to leaks in the aluminum foil), Heptral is not recommended to be used.

Elderly patients

Clinical experience with the use of the drug Heptral did not reveal any differences in its effectiveness in elderly patients and younger patients. However, given the high likelihood of existing violations of the liver, kidneys or heart, other concomitant pathology or simultaneous therapy with other drugs, the dose of Heptral for elderly patients should be selected with caution, starting with the lower limit of the dose range.

Renal failure

There are limited clinical data on the use of the Heptral drug in patients with renal insufficiency, therefore, it is recommended to be careful when using the Heptral drug in such patients.
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Buy Heptral (Ademetionine)

About Ademetionine

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Contraindications and special precautions

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