Buy Sonata (Zaleplon)

The pros of Zaleplon can be significant disadvantages in some circumstances.

In the case of senile insomnia and premature awakenings, the drug is ineffective.

Sonata allows you to fall asleep, but in case of premature awakening, you may not be able to fall asleep again due to the short duration of the action. 

The duration of treatment should not exceed 2 weeks.

 

Take Sonata immediately before going to bed (2 hours after a meal) or after you feel unable to fall asleep.

 

Recommended dosage for adults is 10 mg. The maximum daily dose is 10 mg. Do not to take another dose of the drug during one night!

 

In case of renal insufficiency of mild and moderate degrees of severity, no dose correction is required. There are no data on drug safety in patients with severe renal insufficiency, therefore, the use of the drug in this group of patients is contraindicated.

 

Childhood: there are no data on drug use in children under 18 years of age, therefore, administration of the drug in children under 18 years of age is contraindicated.

According to the study, Zaleplon, unlike other Z-hypnotics, may not cause tolerance and rebound effects.

According to another study, zaleplon may have fewer side effects compared to benzodiazepines

Sonata may be the safest in terms of next-day sedation, and − unlike zolpidem and zopiclone − zaleplon has been found to have no association with increased motor vehicle accidents even when taken for middle-of-the-night insomnia due to its ultrashort elimination half-life. Studies:  1 , 2 , 3 , 4

Zolpidem (Ambien, Ambien CR, Intermezzo, Zolpimist, Edluar, Ivadal, Sanval, etc.) elimination half-life ranges from 1.4 to 4.5 hours. 

Zopiclone (Imovane, Zimovane, Somnol, etc.) elimination half-life ranges from 3.5 to 6.5 hours (5 hours on average). The therapeutic effect occurs within 20-30 minutes.

Zaleplon (Sonata, Starnoc, Andante) elimination half-life is about 1–1.5 hours. The absorption rate of zaleplon is rapid and the onset of therapeutic effects is typically breached within 5–15 minutes following ingestion.

 

• Taking benzodiazepines and short-acting benzodiazepine-like drugs for several weeks may be accompanied by a decrease in the hypnotic effect.

 

• Taking benzodiazepines and benzodiazepine-like drugs can lead to physical and mental addiction, the likelihood of which is associated with taking large doses of the drug, long-term treatment, alcohol and drug addiction.

 

• In case of formed physical dependence, a sharp withdrawal of the drug leads to the development of symptoms of "withdrawal" syndrome: headache, muscle pain, a strong anxiety, increased tension and irritability, psychomotor agitation, confusion of consciousness. In severe cases auto aggression, depersonalization, hearing loss, paresthesia in the extremities, increased response to light, sound and physical stimuli, hallucinations and epileptic seizures are possible.

 

• Benzodiazepines and benzodiazepine-like drugs can cause anterograde amnesia and psychomotor disorders. In order to avoid the development of these symptoms, the drug should only be taken when patients have the possibility of uninterrupted sleep for at least 4 hours after taking the medication.

 

• Treatment with Zaleplon should be discontinued in the event of hypervigilance, irritability, aggressiveness, extraversion, perception and thinking disorders, "nightmare" dreams, hallucinations, psychotic disorders and especially behavioural disorders. Older patients are most likely to develop these symptoms.

 

• The combination of alcohol and Zaleplon can result in fatal respiratory depression and asphyxiation from vomiting.

 

 

Aviation use

The Federal Aviation Administration allows Zaleplon with a 6-hour wait period and no more than twice a week, which makes it the sleep medication with the shortest allowed waiting period after use.

 

Military use

The United States Air Force uses Zaleplon as one of the hypnotics approved as a "no-go pill" to help aviators and special-duty personnel sleep in support of mission readiness. The other hypnotics used as "no-go pills" are temazepam and zolpidem, which both have longer mandatory recovery periods.

• Immune system: very rare - anaphylactic/anaphylactoid reactions.

 

• On the metabolic and nutritional side: very rarely - reduced appetite.

 

• Mental disorders: infrequent - depersonalization, hallucinations, depression, confusion, apathy; frequency unknown - somnabulism.

 

• Nervous system disorders: often - amnesia, paresthesia, drowsiness; infrequently - ataxia/coordination disorders; dizziness, attention disorders, parosmia, speech disorders (dysarthria, slurred speech), hypoesthesia.

 

• From the side of the visual organ: infrequent - vision impairment, diplopia.

 

• On the part of the hearing organ and maze disorders: rarely - hyperacoustic.

 

• Gastrointestinal tract: nausea is not frequent.

 

• Liver and biliary tract: frequency unknown - hepatotoxicity (increased activity of liver enzymes).

 

• Skin and subcutaneous tissues: photosensitization reactions are rare; frequency is unknown - angioedema.

 

• The reproductive system and breast: often - dysmenorrhea.

 

• General disorders and complications at the injection site: infrequently - asthenia, malaise.

 

 

The most common unwanted effects are amnesia, paresthesia, drowsiness and dysmenorrhea.

A full description of Sonata is available here (PDF).

- Hypersensitivity to Zaleplon or any component of the drug;

- Intermediate liver failure (for a given dosage form of the drug);

- Severe liver insufficiency;

- Severe renal failure;

- Night sleep apnea syndrome;

- Severe lung failure;

- Myasthenia;

- Acute respiratory failure;

- Breastfeeding period;

- Lactase deficiency, lactose intolerance, glucose-galactose malabsorption;

- Children under 18 years of age;

- Older age (for this form of medicine)

 

 

Use in pregnancy and lactation

 

There is no data on the use of Zaleplon during pregnancy, so its use during pregnancy is not recommended. 

 

In case of application of large doses of Zaleplon before childbirth the newborn may develop hypothermia, muscle hypotension, moderate respiratory insufficiency.

 

Zaleplon penetrates into breast milk, so its reception during the breastfeeding period is contraindicated.

Like benzodiazepines and other benzodiazepine-like drugs, an overdose does not cause a life-threatening condition if Zaleplon is not taken in combination with other drugs that depress the CNS, including alcohol. In case of overdose, never forget the possibility of combined intoxication.

 

Symptoms of overdose

Cognitive decline from drowsiness to coma. In case of mild poisoning, sleepiness, confusion, lethargy, in more severe cases - ataxia, muscle hypotension, lowering blood pressure, depressed breathing, staining of urine in the blue-green color (a sign of chromaturia), less often coma, in very rare cases with fatal outcome.

 

Treatment

Flumazenil is the antagonist of Zaleplon, which can be used as an antidote for overdose. In the first hour after an overdose, a patient who is conscious should be induced to vomit; a patient who is unconscious should be washed out of the stomach, and activated carbon should be prescribed. Monitoring of cardiac and respiratory activity is conducted in the intensive care unit.

Composition per 1 capsule:

Active ingredient: Zaleplon - 10.00 mg;

Auxiliaries: microcrystalline cellulose - 72.00 mg, lactose monohydrate - 71.01 mg, colloidal silicon dioxide - 0.85 mg, sodium lauryl sulfate - 6.80 mg, sodium carboxymethyl starch - 8.50 mg, magnesium stearate - 0.85 mg.

Auxiliary substances (capsule number 3) - body: iron oxide colorant black - 0,0300 %, azorabine- 0,0429 %, iron oxide colorant red - 0,1600 %, titanium dioxide - 2,3333 %, gelatin - to 100,00 %.
Auxiliary substances (capsule number 3) - lid: indigo carmine colorant - 0,0471 %, titanium dioxide - 1,0000 %, gelatin - up to 100,00 %.

The cost of 20 capsules of 10 mg is $ 40, shipping is already included in the price of the product.

You can buy Sonata (Zaleplon) from our website absolutely legally.

Delivery is carried out to all countries in the world, which do not have an official ban on receiving and sending mail (mainly island countries).

We guarantee that you will receive your parcel with Sonata (Zaleplon) without any problems at customs (we have our own delivery channels to countries with strict customs).

We guarantee a refund if your package has not been delivered to you for any reason, according to PayPal protection policy.

Due to Quarantine, delivery time may increase slightly, but still delivery remains within reasonable limits and does not exceed the delivery time during Christmas sales.

There is no prescription required!

You can legally buy Sonata (Zaleplon) on our website without prescription!