Buy Metformin online. PayPal

Pharmacological group: Antidiabetic agents - biguanides.

Dosage form: tablets (500 mg, 850 mg, 1000 mg).

Release form: One package of Metformin consists of 30 or 60 tablets.

Metformin hydrochloride is a tablet preparation for the treatment of diabetes mellitus of the biguanide class, which has the ability to reduce weight, so it is often used for weight loss.

Available in the market under the trade marks: Metformin, Siofor, Bagomet, Metfogamma, Glicon, Metaspanin, Gliiformin, Gliminfor, Sofamet, Formethine, Langerin, Metadiene, Formin Pliva, NovoFormin, Diaformin.

Metformin has virtually no side effects when properly applied and is not hazardous to health, unlike most other fat burners.

Metformin reduces the level of harmful cholesterol and glucose, which are often increased with excess weight.

A new study by Cardiff University, UK, 2014, which involved 180,000 people, showed that metformin increases life expectancy not only in diabetic patients, but also in individuals who do not suffer from this disease. Also, data were obtained on the slowing down of aging processes on the background of treatment.

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Metformin reduces the concentration of glucose in the blood by inhibiting the formation of glucose (gluconeogenesis) in the liver. In a patient with type 2 diabetes mellitus, the rate of gluconeogenesis is 3 times higher than normal. Metformin reduces this figure by more than one third. The drug also activates AMP-activated protein kinase (AMPK) - a liver enzyme that plays an important role in insulin signaling, in the entire energy balance of the body and in the metabolism of glucose and fats. Activation of AMPK is required for the inhibitory effect of metformin on gluconeogenesis in the liver.

In addition to inhibiting hepatic gluconeogenesis, metformin increases tissue sensitivity to insulin, enhances peripheral glucose uptake (by phosphorylation of the GLUT4 transporter), increases fatty acid oxidation, and decreases glucose absorption from the gastrointestinal tract. The increase in peripheral glucose utilization may be associated with improved insulin binding to insulin receptors [34] AMPK probably also plays a role, since the administration of metformin increases AMPK activity in skeletal muscle.

The drug reduces the concentration of TG, cholesterol and low-density lipoproteins (determined on an empty stomach) in the blood serum and does not change the concentration of lipoproteins of other densities. Stabilizes or reduces body weight. In the absence of insulin in the blood, the therapeutic effect is not manifested. Does not cause hypoglycemic reactions. Improves the fibrinolytic properties of the blood by suppressing the inhibitor of the activator profibrinolysin (plasminogen) of the tissue type.
Metformin is a safe drug, and approved by official medicine for use by healthy people for weight loss.

Follow the diet for weight loss;

Eliminate fast carbohydrates;

Metformin for weight loss is taken immediately before meals or during meals, the dose is selected individually. Most often appoint 500-850 mg, 2-3 times a day (the maximum dose is not more than 3000 mg / day);

If you have diarrhea, then you are abusing carbohydrates;

If you experience nausea after taking metformin, reduce the dose. Slow increase in dose may improve gastrointestinal tolerance;

Carry out systematic aerobic workouts for maximum effectiveness of the course;

If after a decrease in dosage, the symptoms of side effects are not lost, stop taking the drug!
Do not take a metformin for weight loss, if you have:

Kidney disease, accompanied by insufficiency;

Heart failure;

Another disease in which blood acidity is increased;

Do not take glucose with other sugar-reducing drugs and other drugs, without consulting a doctor;

With caution: Age over 60 years, performing heavy physical work (increased risk of developing lactic acidosis).

Possible side effects of metformin (rare):

Diarrhea (it is necessary to reduce the amount of carbohydrates consumed);

Headache (usually fast);

Abdominal cramps;

Nausea (it is necessary to reduce the dose of metformin);

Increased gas formation (it is necessary to reduce the amount of carbohydrates consumed);

Lactoacidosis (in the presence of predisposing diseases), (do not combine with alcohol !!! danger of developing lactocidosis).

As a rule, side effects of metformin occur at the beginning of the course, and then quickly pass.

Other side effects

Metformin has also been found to reduce blood levels of thyroid-stimulating hormone in patients with hypothyroidism, and in men it reduces testosterone levels. The clinical significance of these changes is still unknown. If you are allergic to the drug, a skin rash is possible. In isolated cases, megaloblastic anemia develops. In cases of side effects, the dose should be reduced or the drug should be discontinued.
Metformin is increasingly used in the treatment of polycystic ovary syndrome (PCOS), non-alcoholic fatty liver disease, and precocious puberty, other conditions that present with insulin resistance. These indications are still considered experimental. The benefit of metformin in non-alcoholic fatty liver disease has not been widely studied, although some randomized controlled trials have found significant improvement with its use, the evidence is still insufficient.
Incompatible with ethanol (lactate acidosis). Be wary appoint in combination with indirect anticoagulants.

Sulfonylureas, insulin, acarbose, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate, cyclophosphamide and salicylates enhance the effect.

With simultaneous use with GCS, hormonal contraceptives for oral administration, epinephrine, glucagon, thyroid hormones, phenothiazine derivatives, thiazide diuretics, nicotinic acid derivatives, it is possible to reduce the hypoglycemic effect of metformin.

Nifedipine increases absorption, slows down excretion.
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Buy Metformin

Mechanism of action

Metformin cycle for weight loss

Side effects and contradictions

Use to treat other diseases

Interaction with other drugs

Is it legal to buy Metformin online?

Do I need a prescription to buy Metformin?