Buy Plaquenil 200mg 30tab/60tab online 
 
 
Active substance:
Hydroxychloroquine
 
Manufacturer:
Sanofi Synthelabo (UK)
or
Sanofi Aventis SA (Spain) 
 
Pharmachologic effect:
immunosuppressive, anti-inflammatory, antimalarial, antiprotozoal.
 
Plaquenil has anti-malarial properties and also has anti-inflammatory and immunosuppressive effects in chronic discoid or systemic lupus erythematosus (SLE) and acute and chronic rheumatoid arthritis (RA). The mechanism of its action in malaria, SLE and RA is not fully known.
Plaquenil has the properties of a moderate immunosuppressor, inhibiting the synthesis of rheumatoid factor and components of the acute phase reaction. It also accumulates in leukocytes, stabilizing lysosomal membranes, and inhibits the activity of many enzymes, including collagenases and proteases that cause cartilage breakdown.
 
Efficiency in SLE and RA is associated with the following anti-inflammatory and immunomodulating effects of Plaquenil:
 
- an increase in intracellular pH slows down the antigenic response and reduces the binding of peptides of the receptors of the main histocompatibility complex (MHC). A smaller number of antigen-MHC receptors reaches the cell surface, which leads to a decrease in the autoimmune response;
 
- a decrease in the activity of phospholipase A2 at high concentrations of lysosomal enzymes;
 
- a decrease in the concentrations of IL-1 and IL-6 cytokines, leading to a decrease in the clinical and laboratory parameters of the autoimmune response. Since there is no violation of the synthesis of interferon gamma, these effects may be associated with a selective effect on cytokines;
 
- inhibition of pre- and / or post-transcription of DNA and RNA.
 
The drug actively suppresses asexual erythrocyte forms, as well as the gametes Plasmodium vivax and Plasmodium malariae, which disappear from the blood almost simultaneously with asexual forms. Plaquenil does not affect Plasmodium falciparum gametes. Plaquenil is ineffective against chloroquine-resistant strains of Plasmodium falciparum, and is also inactive against extra-erythrocytic forms of Plasmodium vivax, Plasmodium malariae and Plasmodium ovale and therefore cannot prevent infection with these microorganisms when it is prescribed for prophylactic purposes, and also cannot prevent a relapse these pathogens.
 
 
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