Buy Ursofalk (Ursodeoxycholic acid)

Ursodeoxycholic acid inhibits the synthesis in the liver and the secretion of cholesterol, and also inhibits its absorption in the intestine. Apparently, Ursofalk has a slight inhibitory effect on the synthesis and secretion of endogenous bile acids into bile and, apparently, does not affect the secretion of phospholipids into bile. With regular use, the concentration of UDCA in bile reaches an equilibrium state after about 3 weeks.

UDCA solubilizes cholesterol and is incorporated into micelles. It also acts, presumably, by a unique mechanism, causing the dispersion of cholesterol in the form of liquid crystals in an aqueous medium. As a consequence, even with the introduction of high doses (for example, 15–18 mg / kg / day), a concentration of UDCA above 60% of the total amount of bile acids is not achieved. Bile, rich in UDCA, effectively solubilizes cholesterol. The overall effect of UDCA is to increase cholesterol levels. The different mechanisms of action of UDCA combine to alter the state of bile in patients with gallstones, which helps dissolve cholesterol stones. After stopping the administration of UDCA, the concentration of this bile acid in bile falls exponentially, decreasing to approximately 5–10% of its steady state level in about 1 week.

Other mechanisms of action include cytoprotection of the epithelium of cells of the damaged bile duct (cholangiocytes) from the toxic effect of bile acids, inhibition of hepatocyte apoptosis, immunomodulatory action and stimulation of bile secretion by hepatocytes and cholangiocytes.

• hypersensitivity;
• X-ray positive (high calcium) gallstones;
• non-functioning gallbladder;
• acute inflammatory diseases of the gallbladder, bile ducts and intestines;
• liver cirrhosis in the stage of decompensation;
• severe impaired renal function, liver, pancreas.

Ursodeoxycholic acid has no age restrictions for use, but children under 3 years of age are advised to use UDCA in the form of a suspension, since it may be difficult to swallow capsules

The use of the drug during pregnancy and lactation is possible if the expected effect of therapy outweighs the potential risk to the fetus (no studies have been carried out). For women of childbearing age, contraception is required while taking the drug.

• Diarrhea,
• nausea,
• pain in the epigastric region and right hypochondrium,
• alcification of gallstones, increased activity of hepatic transaminases,
• allergic reactions.

In the treatment of primary biliary cirrhosis, transient decompensation of liver cirrhosis may occur, which disappears after discontinuation of the drug.

Overdose

Symptoms: diarrhea. As a rule, other symptoms of an overdose are unlikely, since with an increase in the dose, the absorption of UDCA decreases and, accordingly, more of it is excreted in the faeces.

Treatment: symptomatic, aimed at replenishing the volume of fluid and restoring the electrolyte balance. There is no need to take specific measures for overdose.

Orally. Children and adults weighing less than 47 kg, as well as patients who cannot swallow Ursofalk in the form of film-coated tablets, are recommended to use Ursofalk in the form of a suspension. 

For more detailed dosage information see leaflet.

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You can legally buy Ursofalk (Ursodeoxycholic acid) on our website without prescription.

Antacids containing aluminum and ion exchange resins (cholestyramine) reduce absorption.

Cholestyramine, colestipol and antacids containing aluminum hydroxide or smectite (aluminum oxide) reduce the absorption of UDCA in the intestine and thus reduce its absorption and effectiveness. If the use of drugs containing at least one of these substances is still necessary, they must be taken at least 2 hours before taking Ursofalk.

Lipid-lowering drugs (especially clofibrate), estrogens, neomycin, or progestins increase cholesterol saturation in bile and may decrease the ability to dissolve cholesterol gallstones.

UDCA can enhance the absorption of cyclosporine from the intestine. Therefore, in patients taking cyclosporine, the doctor should check the concentration of cyclosporine in the blood and, if necessary, adjust the dose. In some cases, Ursofalk can reduce the absorption of ciprofloxacin.

There are also reports of interaction with dapsone, which led to a decrease in the therapeutic effect of the latter. These observations, along with data from in vitro experiments, suggest that UDCA is capable of inducing isozymes of the cytochrome P450 CYP3A system. However, in a planned study of interaction with budesonide, which is a known substrate of cytochrome P450 CYP3A, induction was not observed.

Estrogenic hormones and drugs that lower the level of cholesterol in the blood, such as clofibrate, increase the secretion of cholesterol in the liver and, therefore, can stimulate the formation of gallstones, which negates the effect of UDCA, which is used to dissolve gallstones.